The cruise ship has been sailing in the Adriatic in the summer and in the Seychelles in the winter.
"The decision to reposition Crystal Esprit to the West Indies is one that was made with our guests' expressed wishes in mind," Crystal CEO Edie Rodriguez said.
She added passengers particularly wanted closer proximity to major travel hubs.
The Esprit will sail roundtrip on Sundays from Marigot Bay, Saint Martin, on two alternating 7-day routes. One itinerary will feature calls in St. Barthelemy and four locations in the British Virgin Islands.
A second itinerary will take the Esprit to Anguilla, Saba, Nevis, St. Barthelemy and St. Martin.