The liner will homeport in Piraeus-Athens during the entire season.
MSC Lirica will sail on a newly-designed 7-night roundtrip itinerary with a total of 28 voyages planned for April-October 2022. From Piraeus are visited Kusadasi (Ephesus, Turkey), Haifa (Tel Aviv-Nazareth, Israel), Limassol (Cyprus), and the Greek islands of Santorini and Rhodes before returning to Piraeus.
The passengers can also begin their 7-night voyages with embarkation at Piraeus, Kusadasi, Haifa, and Limassol.
Crete Island (Heraklion) will also be a port of call in the four 11-night sailings of MSC Lirica in the Eastern Mediterranean during November & December 2022 with calls at Heraklion.
Greece also features in 3 other Eastern Mediterranean itineraries.
MSC Armonia will call at Piraeus on a weekly basis during summer 2022. From September 2022, MSC Fantasia will similarly perform 11-night voyages to the Greek port for vacationers to visit Athens. MSC Musica's summer 2022 program includes as call ports Katakolon-Olympia, Heraklion Crete and Santorini (Thira).