New Madrid MO is a Mississippi River cruise port and town in Missouri USA, with total area approx 12 km2 (5 ml2) and population around 3,000. The town is approx 68 km (42 ml) south-west of Cairo (Illinois).
The town was established in 1778 as part of Spanish Louisiana (west of Mississippi River). Here the river curves in an oxbow and eventually could cut across peninsula's neck and make a direct channel. The region was processed as cotton plantations. By early-20th-century, the town had 2 lumber mills, grist mill, cotton gin, stave and heading factory, 1 Catholic and 4 Protestant churches.
The area is noted for over 1000 earthquakes in the period 1811-1812, ranging up to Richter magnitude 8.