- The current town's built over a Roman settlement (named Bauconica Nova). In 742 AD, the town (as Nierstein) was first mentioned in a donation document.
- The amateur palaeontologists Arnulf (father) and Harald (son) Stapf built the Palaontologisches Museum Nierstein, housing rare footprints of amphibians, reptiles and insects from Permian period (47 million years ago), along with unique fossils from around the world. Since some of these specimens are truly unique, the museum is visited also by many renown international specialists.
- Town economy's 2nd largest contributor is tourism, mainly cyclists, hikers and day tourists. The town has 7 hotels and over 20 guesthouses, most of which are in renovated wineries.
Port Nierstein cruise ship schedule shows timetable calendars of all arrival and departure dates by month. The port's schedule lists all ships (in links) with cruises going to or leaving from Nierstein, Germany. To see the full itineraries (ports of call dates and arrival / departure times) and their lowest rates – just follow the corresponding ship-link.